Real selective lighting will be possible with WebGPURenderer
.
Demo: three.js - WebGPU - Selective Lights
You need Chrome Canary with enabled WebGPU flag to check out the example.
In WebGLRenderer
you can try to use multiple scenes to achieve something similar (see https://github.com/mrdoob/three.js/issues/5180#issuecomment-54812294).