Does "is typically done one time" apply to "geometry.applyMatrix4"?

Questions
1

In the documentation:
"This is typically done as a one time operation, and not during a loop. "
This is said for geometry .lookAt(), .rotateX(), .scale(), and .translate().
Shouldn’t it be said for geometry applyMatrix4 also?

2

Yes, you’re correct. Should apply to .center() as well.